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Research Programs

All Research Programs

CARD is a uniquely collaborative center. We focus on projects with the potential to produce valuable data, resources, and tools for others working on Alzheimer’s and related dementias (AD/ADRD). All of our projects connect and complement one another, and benefit from the diverse skills and expertise of our expert groups.

Research at CARD

  • An illustration of brightly colored neurons in various stages of development.

    iPSC Neurodegenerative Disease Initiative (iNDI)

    Harnessing data from cell models of AD/ADRD may help explain disease biology. Access our cell lines and related datasets.

  • A illustration of the process of nanopore DNA sequencing, showing a long piece of DNA traveling through a pore.

    Long-read Sequencing

    Large-scale long-read DNA sequencing efforts can help us understand the genetics of AD/ADRD. Explore our datasets.

  • Illustration of a scientist looking at a sculpture of a person’s brain. A ladder rests against the sculpture, leading to a window that reveals protein aggregation in the brain.

    AutoTAC (Tau Protein Aggregates)

    We aim to de-risk therapeutic strategies for AD/ADRD, such as an approach to eliminate protein aggregates in the brain.

  • An illustration of an aerial map of a park, with paths through the park that cut the outline and shape of a brain.

    Brain Atlas

    We’re working to reveal differences between healthy and AD/ADRD brains at the cellular level. Explore the data.

  • Abstract illustration of a protein with folds and a novel region represented in red.

    TDP-43

    We need easier ways to detect AD/ADRD. One approach involves looking for signs of abnormal sections of RNA.

  • An illustrative representation of organoids

    Molecular Pathology Unit

    Organoids that mimic the human brain can help us investigate the roles and interplay between different brain cell types in dementia biology.

  • An illustration that shows a collage of icons including a text box, data charts, and a mouth speaking.

    Challenge: Propose a Research Program

    Any NIH staff member, researcher or collaborator can suggest a new research topic for CARD. Submit an idea!

CARD Expert Groups

Explore our Expert Group staff, who support all of our research programs.

Read about expert groups
Researchers in a conference room listening to alzheimers proposal opportunities.