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New building and other updates from the NIH Center for Alzheimer’s and Related Dementias

Andrew SINGLETONCenter Director, Center for Alzheimer’s and Related Dementias (CARD).

The Center for Alzheimer’s and Related Dementias (CARD), a collaborative NIH Intramural Research Program initiative of NIA and the National Institute of Neurological Disorders and Stroke, continues to progress as a dynamic resource in the fight against these diseases. Today, CARD’s new home, the Roy Blunt Center for Alzheimer’s Disease and Related Dementias Research, a state-of-the-art building located on the NIH Bethesda campus, will be officially dedicated during an afternoon ceremony. U.S. Senator Roy Blunt (MO) is the distinguished guest of honor for the event, which will be broadcast live starting at 2:00 p.m. ET on the NIH Videocast website.

Through the CARD program, which has been evolving since its establishment in 2020, dementia researchers have already made significant gains. Read on for a few examples!

A powerful portal for stem cell research

CARD supports the largest-ever genome engineering project for human induced pluripotent stem cells (iPSCs), known as the iPSC Neurodegenerative Disease Initiative, or the iNDI project. Recently, iNDI project researchers launched a new online portal for scientists to access a catalog of neurodegenerative disease human iPSC lines. The portal is a powerful research catalyst and contains more than 100 variants associated with Alzheimer’s and related dementias across 73 genes.

Through rigorous scientific collaboration with the iNDI project, the portal team selects, validates, and quality controls Alzheimer’s and related dementias cell lines and their genetically matched controls. It dramatically reduces the effort and expense for researchers to adopt iPSC models in their own programs and creates a standard for the Alzheimer’s and related dementias research enterprises. You can learn more about cell selection for the catalog or browse the available cell collection.

Training and career development opportunities at CARD

One of CARD’s core focus areas is career development and training for a diverse next generation of Alzheimer’s and related dementias researchers. CARD researchers understand that an ethnically, racially, and culturally diverse team is critical for advancing the most innovative scientific ideas. We are currently accepting applications for postdoctoral scientist fellows. Successful candidates will gain training and experience designing and running independent research programs to help build their scientific and management skills. CARD fellows will play a substantial role in the design and implementation of the center’s research priorities. In addition, they’ll have access to a mentoring committee of preeminent researchers in the field. Apply for a fellowship today!

CARD is also actively seeking applicants for its Alzheimer’s and Related Dementias Independent Scholars (ARDIS) program. This exciting career development opportunity offers early-career researchers a time-limited, independent principal investigator appointment, generous resources — including a standard operating budget and up to two postbaccalaureate fellows or other technical staff! — and access to CARD and other NIH research cores and infrastructure.

Additionally, we are recruiting full-time staff to fill out our winning hand. We’re seeking tenure-track investigators to develop an independent research program focused on either or both of the following thematic areas:

  • Modern molecular neuropathology, specifically to investigate the basis of Alzheimer’s and related dementias using donated human samples
  • Translating knowledge of the genetic basis of Alzheimer’s and related dementias into biological understanding of disease processes using a functional genetics and/or genomics approach

While CARD is still growing, this crucial initiative already provides a wealth of opportunities to collaborate and advance your career. To learn more, please visit